全文获取类型
收费全文 | 3240篇 |
免费 | 123篇 |
国内免费 | 13篇 |
学科分类
医药卫生 | 3376篇 |
出版年
2023年 | 7篇 |
2022年 | 6篇 |
2021年 | 43篇 |
2020年 | 33篇 |
2019年 | 36篇 |
2018年 | 60篇 |
2017年 | 32篇 |
2016年 | 70篇 |
2015年 | 43篇 |
2014年 | 79篇 |
2013年 | 105篇 |
2012年 | 171篇 |
2011年 | 215篇 |
2010年 | 116篇 |
2009年 | 115篇 |
2008年 | 196篇 |
2007年 | 192篇 |
2006年 | 187篇 |
2005年 | 230篇 |
2004年 | 236篇 |
2003年 | 207篇 |
2002年 | 219篇 |
2001年 | 52篇 |
2000年 | 33篇 |
1999年 | 51篇 |
1998年 | 44篇 |
1997年 | 54篇 |
1996年 | 33篇 |
1995年 | 42篇 |
1994年 | 34篇 |
1993年 | 37篇 |
1992年 | 37篇 |
1991年 | 35篇 |
1990年 | 24篇 |
1989年 | 30篇 |
1988年 | 31篇 |
1987年 | 16篇 |
1986年 | 24篇 |
1985年 | 28篇 |
1984年 | 31篇 |
1983年 | 17篇 |
1982年 | 13篇 |
1981年 | 14篇 |
1980年 | 11篇 |
1979年 | 8篇 |
1978年 | 15篇 |
1974年 | 6篇 |
1972年 | 6篇 |
1968年 | 7篇 |
1966年 | 8篇 |
排序方式: 共有3376条查询结果,搜索用时 313 毫秒
91.
92.
Mohsen Vigeh Emiko Nishioka Kazuhito Yokoyama Katsumi Ohtani Takehisa Matsukawa 《Hypertension in pregnancy》2016,35(4):583-592
Objective: Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined. Methods: To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined. Results: Early pregnancy blood Mn was significantly (p < 0.05) correlated with blood pressure through gestation. A significant association between odds of pre-hypertension with blood Mn was shown (OR:1.150, 95% CI:1.052–1.258). Conclusion: The current study results might suggest the blood Mn level during early stage of pregnancy as a potential risk factor for increasing the risk of gestational blood pressure. 相似文献
93.
Hisashi Kaneda Masaki Shimizu Kazuhide Ohta Katsumi Ushijima Yoshimitsu Gotoh Kenichi Satomura Takuhito Nagai Mikiya Fujieda Masashi Morooka Takuji Yamada Masayoshi Yamada Naohiro Wada Mari Takaai Yukiya Hashimoto Osamu Uemura 《Clinical and experimental nephrology》2016,20(5):757-763
Background
The present study aimed to obtain information enabling optimisation of the clinical effect of mizoribine (MZR) in pediatric patients with kidney disease.Methods
A total of 105 pediatric patients with kidney disease treated at our institutions were enrolled. Kidney transplant patients were excluded. Population pharmacokinetic analysis of MZR was performed based on serum concentration data. Area under the curve from time zero to infinity (AUC∞) and maximal concentration (C max) were calculated by Bayesian analysis.Results
In children, the appearance of MZR in the blood tended to be slower and the subsequent rise in blood concentration tended to be more sluggish, compared to healthy adults. Apparent volume of distribution and oral clearance were also higher in children compared to adults. A significant positive correlation was observed between patient age and AUC∞. There were significant differences of AUC∞ and C max by age group. No relationship was observed between the administration method of MZR and serum concentration.Conclusion
The pharmacokinetics of MZR was different in children compared to adults. To obtain the expected clinical efficacy, the regular MZR dosage schedule (2–3 mg/kg/day) might be insufficient for pediatric patients. In particular, younger patients might require a higher dosage of MZR per unit body weight.94.
Kasirawat Sawangrat Masaki Morishita Kosuke Kusamori Hidemasa Katsumi Toshiyasu Sakane Akira Yamamoto 《Journal of pharmaceutical sciences》2018,107(11):2946-2956
Breast cancer resistance protein (BCRP) transporter is an efflux transporter that utilizes energy from adenosine triphosphate hydrolysis to push its substrates, regardless of the concentration gradient. Its presence on the apical membrane of the intestinal mucosa is a major obstacle for the intestinal absorption of its substrates. In this study, we examined the effects of various pharmaceutical excipients on the intestinal transport and absorption of sulfasalazine, a BCRP substrate. Four excipients, including 0.05% and 0.075% BL-9EX, 0.01% and 0.05% Brij 97, 0.075% Labrasol, and 0.05% and 0.1% Tween 20 decreased the secretory transport of sulfasalazine in an in vitro diffusion chamber. Further investigation in an in situ closed loop experiment in rats showed that 0.05% and 0.1% BL-9EX and 0.1% Brij 97 effectively enhanced the intestinal absorption of sulfasalazine while maintaining minimal toxicity to the intestinal mucosa. However, 0.1% Brij 97 also increased the intestinal absorption of 5(6)-carboxyfluorescein, a paracellular marker compound. These findings suggest that BL-9EX might effectively inhibit the BCRP-mediated efflux of sulfasalazine in vivo, indicating that BL-9EX could improve the intestinal absorption of sulfasalazine and other BCRP substrates. 相似文献
95.
Thirteen week toxicity study of dietary l‐tryptophan in rats with a recovery period of 5 weeks 下载免费PDF全文
Yusuke Shibui Hideki Matsumoto Yoko Masuzawa Takumi Ohishi Tsutomu Fukuwatari Katsumi Shibata Ryosei Sakai 《Journal of applied toxicology : JAT》2018,38(4):552-563
Although l ‐tryptophan is nutritionally important and widely used in medical applications, toxicity data for its oral administration are limited. The purpose of this study was to evaluate the potential toxicity of an experimental diet containing added l ‐tryptophan at doses of 0 (basal diet), 1.25%, 2.5% and 5.0% when administered to Sprague–Dawley rats for 13 weeks. There were no toxicological changes in clinical signs, ophthalmology, urinalysis, hematology, necropsy, organ weight and histopathology between control rats and those fed additional l ‐tryptophan. Body weight gain and food consumption significantly decreased throughout the administration period in males in the 2.5% group and in both sexes in the 5.0% group. At the end of the dosing period, decreases in water intake in males in the 5.0% group and in serum glucose in females in the 5.0% group were observed. The changes described above were considered toxicologically significant; however, they were not observed after a 5 week recovery period, suggesting reversibility. Consequently, the no‐observed‐adverse‐effect level of l ‐tryptophan in the present study was 1.25% for males and 2.5% for females (mean intake of l ‐tryptophan: 779 mg kg–1 body weight day–1 [males] and 1765 mg kg–1 body weight day–1 [females]). As the basal diet used in this study contained 0.27% of proteinaceous l ‐tryptophan, the no‐observed‐adverse‐effect level of overall l ‐tryptophan was 1.52% for males and 2.77% for females (mean intake of overall l ‐tryptophan: 948 mg kg–1 body weight day–1 (males) and 1956 mg kg–1 body weight day–1 (females)). We conclude that l ‐tryptophan has a low toxicity profile in terms of human use. 相似文献
96.
97.
98.
Nakashima M Yano H Akita S Tokunaga K Anraku K Tanaka K Hirano A 《The Journal of craniofacial surgery》2007,18(6):1466-1470
Forward dislocation of the temporomandibular joint commonly can be easily diagnosed and successfully reduced by manual repositioning. In this report, we discuss a rare case of prolonged temporomandibular dislocation that had persisted for more than 20 years because the otolaryngologist and dentist had missed the dislocation. This patient underwent open reduction and mandibular joint plasty with preoperative orthodontic therapy. It is possible that strong pain and mouth-closing disability may gradually remit and only deviated mandibular prognathism like malocclusion may persist. Therefore, abnormal occlusion warrants careful attention to temporomandibular joint dislocation. 相似文献
99.
Daisuke Gotoh MD PhD Nobutaka Shimizu MD PhD Naoki Wada MD PhD Katsumi Kadekawa MD PhD Tetsuichi Saito MD Shinsuke Mizoguchi MD PhD Yosuke Morizawa MD PhD Shunta Hori MD PhD Makito Miyake MD PhD Kazumasa Torimoto MD PhD William C. de Groat PhD Kiyohide Fujimoto MD PhD Naoki Yoshimura MD PhD 《Neurourology and urodynamics》2020,39(8):2120-2127
100.
Yatsuka Hibi Tamae Ohye Kimio Ogawa Yoshimi Shimizu Masahiro Shibata Chikara Kagawa Yutaka Mizuno Shinya Uchino Shinji Kosugi Hiroki Kurahashi Katsumi Iwase 《Surgery today》2014,44(11):2195-2200
We report a rare case with pheochromocytoma as the first manifestation of multiple endocrine neoplasia type 2A with RET mutation S891A. Bilateral pheochromocytomas were identified in a 54-year-old woman. Screening for RET revealed a rare S891A mutation located in the intracellular tyrosine kinase domain. This mutation was previously recognized as one of the mutations only in cases manifesting solely medullary thyroid carcinomas (MTCs). Since calcitonin stimulation test indicated positive result, total thyroidectomy was performed 1 year after the bilateral adrenalectomy, and C-cell hyperplasia was diagnosed by histopathological examination. Our report suggests that cases with S891A mutation, akin to those with other RET mutations, require screening for pheochromocytoma. In addition, it is indicated that calcitonin stimulation test should be performed even in the unaffected elder cases with S891A mutation although the mutation is classified as lowest risk group on MTC in guidelines. 相似文献